Following on from the COVID-19 International Student Well-being Study this collaborative project examines the impact of the COVID-19 pandemic on the health and well-being of students in higher education at five universities in Germany. An online cross-sectional study was conducted, in which different areas of student life were addressed. Students from undergraduate and graduate study programmes were invited to participate in the study. The online survey enabled students to participate in a time-efficient and anonymous way. The resulting data allow to describe the living conditions and well-being during the ongoing COVID-19 pandemic in German student populations.